Non-uniform aspects of the SARS-CoV-2 intraspecies evolution reopen question of its originArticle Published on 2022-12-012022-11-16 Journal: International journal of biological macromolecules [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] acute respiratory syndrome beta-coronavirus Characteristics conducted conserved coronavirus disease Coronavirus-2 COVID-19 distribution Evenly-uneven Evidence Evolution Frequency functional furin cleavage Furin cleavage site (FCS) hypothese Hypothesis Invariant regions Mutation mutations pandemic Pandemics Protein question Region residue residues SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2. Support the SARS-CoV-2 Transmissibility unique variants virulence virus [DOI] 10.1016/j.ijbiomac.2022.09.184 PMC 바로가기
Acquisition of Furin Cleavage Site and Further SARS-CoV-2 Evolution Change the Mechanisms of Viral Entry, Infection Spread, and Cell Signaling푸린 절단 부위의 획득 및 추가 SARS-CoV-2 진화는 바이러스 진입, 감염 확산 및 세포 신호 전달의 메커니즘을 변경합니다Article Published on 2022-08-102022-09-11 Journal: Journal of Virology [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] ACE2 acquisition activate activating Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adaptive immune response alphavirus appear cathepsin Cathepsins Cell Cell fusion change coronavirus COVID COVID-19 disease Cytokines Deletion determined by endosome Entry mechanism entry pathway Evolution experimental system expressing S protein expression FCS furin furin cleavage furin cleavage site hallmark human population immune in vitro induce infected with SARS-CoV-2 infecting Infection inhibitor inhibitors lack leads Lineage mAbs mechanism media mRNA vaccines Neutralizing neutralizing monoclonal antibodies neutralizing monoclonal antibody pro-inflammatory cytokines pro-inflammatory response pseudoinfectious viruses pseudovirus pseudoviruses receptor released respiratory S protein S1 secretion S1 subunit SARS-CoV-2 SARS-CoV-2 pathogenesis SARS-CoV-2 S protein secrete sera severe acute respiratory syndrome Coronavirus shown Site Spike protein Spread spreading Syncytia syncytium syncytium formation the S protein the S1 subunit TLR4 TMPRSS2 TMPRSS2 expression variant Viral viral evolution viral evolution. virus virus entry virus spread [DOI] 10.1128/jvi.00753-22 PMC 바로가기 [Article Type] Article
Evolutionary dynamics of SARS-CoV-2 circulating in Yogyakarta and Central Java, Indonesia: sequence analysis covering furin cleavage site (FCS) region of the spike protein족자카르타와 인도네시아 중부 자바에서 순환하는 SARS-CoV-2의 진화 역학: 스파이크 단백질의 푸린 절단 부위(FCS) 영역을 포괄하는 서열 분석Article Published on 2022-08-012022-09-11 Journal: International microbiology : the official journal [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Analysis cDNA cDNA synthesis circulating clade Cluster Clusters confirmed COVID-19 patients coronavirus COVID-19 pandemic COVID-19 patient D614 variant D614G D614G mutation evolutionary dynamics FCS FIVE furin furin cleavage furin cleavage site G614 variant Genome GISAID indicated Indonesia Mutation Nasopharyngeal swab nasopharyngeal swab sample Nasopharyngeal swab samples new SARS-CoV-2 new virus PCR amplification Protein Q677H Region replaced responsible retrieved RNA SARS-CoV-2 SARS-CoV-2 isolate SARS-CoV-2 isolates sequence Sequence analysis Sequencing severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 silent spike Spike protein spike protein. synthesis the spike protein were used [DOI] 10.1007/s10123-022-00239-8 PMC 바로가기 [Article Type] Article
Study of protease-mediated processes initiating viral infection and cell-cell viral spreading of SARS-CoV-2Article Published on 2022-07-192023-07-10 Journal: Journal of molecular modeling [Category] COVID19(2023년), [키워드] Cell–cell viral spreading furin cleavage SARS-CoV-2 TMPRSS2 cleavage Viral-cell entry. [DOI] 10.1007/s00894-022-05206-8 PMC 바로가기
Furin and TMPRSS2 Resistant Spike Induces Robust Humoral and Cellular Immunity Against SARS-CoV-2 Lethal Infection푸린 및 TMPRSS2 내성 스파이크는 SARS-CoV-2 치명적인 감염에 대한 강력한 체액 및 세포 면역을 유도합니다Article Published on 2022-05-022022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 ACE2 transgenic mice Against Amino acid antibody response against blocked C-terminal CD8 cleavage site clone clones COVID-19 vaccine effective Express furin furin cleavage furin cleavage site hamsters identify in some induce intranasal lethal Mutation mutations produced protective immunity Protein pseudotype Replication replication-competent. Resistant robust S antigen S protein S1/S2 cleavage S1/S2 cleavage site SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 spike protein SARS-CoV-2 variant single dose spike Spike protein T cell T cell response the SARS-CoV-2 TMPRSS2 transgenic unmet need vaccination Vaccine Vaccine design variant vesicular stomatitis vesicular stomatitis virus virus VSV was used [DOI] 10.3389/fimmu.2022.872047 PMC 바로가기 [Article Type] Article
Molecular phylogeny of coronaviruses and host receptors among domestic and close-contact animals reveals subgenome-level conservation, crossover, and divergence국내 및 밀접 접촉 동물 사이의 코로나바이러스 및 숙주 수용체의 분자 계통 발생은 하위 게놈 수준의 보존, 교차 및 분기를 나타냅니다Article Published on 2022-04-012022-09-11 Journal: BMC veterinary research [Category] COVID19(2023년), SARS, 치료법, [키워드] ACE2 ACE2 residue acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 alphacoronavirus alphacoronaviruses aminopeptidase N analyzed angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 animals APN binding cathepsin L cattle Comparative Comparative phylogeny Complete conservation conserved Consistency coronavirus coronavirus Coronavirus-2 Coronaviruses Critical cross determine dipeptidyl peptidase Dipeptidyl peptidase 4 DPP4 enzyme Enzymes events explain Factor furin furin cleavage furin cleavage motif genome sequence Genome sequences Host host receptor Host receptors hosts identify infecting intermediate host Intersection membrane MERS MERS-CoV Middle East Middle East respiratory syndrome Coronavirus molecular N protein N proteins nucleocapsid offer other coronavirus other coronaviruses Phylogenetic tree phylogenies Phylogeny polybasic Protein Protein binding Proteins receptor receptors Recombination respiratory syndrome coronavirus retained reveal S proteins S, E, M, and N proteins SARS-CoV SARS-CoV-2 SARS-CoV-2 spike protein SAS segregation sequence Serine Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 sialic acid similarities similarity spike Spike protein spike protein. Support the S protein theory TMPRSS2 transmembrane serine protease transmembrane serine protease 2 unique Viral protein Viral proteins virus white-tailed deer β-coronavirus β-coronavirus [DOI] 10.1186/s12917-022-03217-4 PMC 바로가기 [Article Type] Article
Capturing a Crucial ‘Disorder-to-Order Transition’ at the Heart of the Coronavirus Molecular Pathology—Triggered by Highly Persistent, Interchangeable Salt-BridgesArticle Published on 2022-02-162022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] anionic appear arginine baseline being binding catalytic cationic characteristic cleavage site coronavirus COVID-19 disorder disorder-to-order transition enthalpy entropy compensation entropy arrest events Evolution feature FLCS flexible furin cleavage Genome heart homologous Host increase in Interaction interactions Lineage Molecular pathology motif multiplicity offer persistent polybasic Protein proteolytic proteolytic cleavage residue respiratory viral diseases respiratory viruses S1/S2 junction salt-bridge salt-bridge dynamics SARS-CoV SARS-CoV-2 spike Spike–Furin interaction the SARS-CoV-2 Transmissibility [DOI] 10.3390/vaccines10020301 PMC 바로가기 [Article Type] Article
Novel Small-Molecule Inhibitors of the SARS-CoV-2 Spike Protein Binding to Neuropilin 1Article Published on 2022-01-282022-10-28 Journal: Pharmaceuticals [Category] COVID-19, [키워드] antagonist binding Cell Compound COVID-19 furin cleavage in vitro binding assay inhibitor molecular docking neuropilin 1 novel NRP1 peptide polybasic Probability responsible SARS-CoV-2 sequence small-molecule antagonists spike spike binding inhibitors Spike protein starting point the SARS-CoV-2 these compound viral entry viral infectivity Virtual screening [DOI] 10.3390/ph15020165 PMC 바로가기 [Article Type] Article
Role of Q675H Mutation in Improving SARS-CoV-2 Spike Interaction with the Furin Binding PocketArticle Published on 2021-12-142022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] Analysis arginine residue binding pocket circulating clades conformations ENhance Evolution evolutionary relationship expressed furin furin cleavage furin cleavage site greater highlight human host Improving Interaction investigated involved Italy Lineage molecular molecular dynamics mutant Mutation new SARS-CoV-2 performed Phylogenesis Phylogenetic pocket polar predicted Prevalence proteolytic Q675H spike mutation role SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 lineage shown spike spike mutation Spike protein viral entry viral fitness Viral protein VoC VOCs [DOI] 10.3390/v13122511 PMC 바로가기 [Article Type] Article
Dynamics prediction of emerging notable spike protein mutations in SARS-CoV-2 implies a need for updated vaccinesSARS-CoV-2에서 떠오르는 주목할만한 스파이크 단백질 돌연변이의 역학 예측은 업데이트된 백신의 필요성을 의미합니다Article Published on 2021-12-012022-09-11 Journal: Biochimie [Category] SARS, 변종, 진단, [키워드] addition Alpha antigenicity B.1.1.7 B.1.351 B.1.617.2 Beta binding cause clade cleavage conformational change COVID-19 D614G Delta dominant variant Dynamics Efficacy exhibited flexibility furin furin cleavage Gamma human cell include lack molecular molecular dynamics Mutation mutation D614G neutralization Nextstrain notable other variant other variants P.1 pathogenicity polybasic predict previous study Protein question RBD Receptor-binding domain SARS-CoV-2 spike Spike protein stability structural biology Structure Superimposition the antibody the receptor-binding domain the spike protein Thermodynamics Vaccine Vaccines. variant variants virus wild type Wuhan [DOI] 10.1016/j.biochi.2021.08.011 PMC 바로가기 [Article Type] Article